SMAC Advisor
نویسندگان
چکیده
This paper presents SMAC Advisor, a decision-support tool for the assessment of coexistence between genetically modified and conventional maize. The assessment is based on a qualitative multi-attribute DEXi model. This model was developed from two sources: (1) extensive simulations of gene flow due to cross-pollination, obtained by a simulator called MAPOD®, and (2) rules provided by experts in agronomy. SMAC Advisor provides a friendly “wizard” interface for its users: farmers, administrative workers and policy makers in agronomy.
منابع مشابه
Cancer Therapy: Preclinical Role of Smac in Determining the Chemotherapeutic Response of Esophageal Squamous Cell Carcinoma
Purpose: Second mitochondria-derived activator of caspase (Smac) regulates chemotherapy-induced apoptosis. Smac mimetics have been tested in clinical trials as chemosensitizers. We determined the role of Smac in modulating the chemosensitivity of esophageal squamous cell carcinoma (ESCC). Experimental Design: Smac expression was evaluated in tissues from ESCC patients with differential chemothe...
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Second mitochondria-derived activator of caspases/direct inhibitor of apoptosis-binding protein with low pI (Smac/DIABLO) is released by mitochondria in response to apoptotic stimuli and is thought to regulate apoptosis by antagonizing inhibitors of apoptosis proteins, which play an important role in sensitization of cancer cells to various therapeutic regimens. The expression of Smac/DIABLO ha...
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Smac/DIABLO, a recently identified inhibitor of apoptosis protein (IAP)-binding protein, is released from the mitochondria during apoptosis and reportedly potentiates apoptosis by relieving the inhibition of IAPs on caspases. We now describe the molecular characterization of Smac beta, an alternatively spliced form of Smac, which lacks the mitochondrial-targeting sequence found in Smac and has ...
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PURPOSE Second mitochondria-derived activator of caspase (Smac) regulates chemotherapy-induced apoptosis. Smac mimetics have been tested in clinical trials as chemosensitizers. We determined the role of Smac in modulating the chemosensitivity of esophageal squamous cell carcinoma (ESCC). EXPERIMENTAL DESIGN Smac expression was evaluated in tissues from ESCC patients with differential chemothe...
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PURPOSE Overexpression of inhibitors of apoptosis proteins (IAP) contributes to therapeutic resistance. Second mitochondria-derived activator of caspase (Smac) promotes caspase activation by binding to IAPs upon release from the mitochondria. IAP antagonists, also called SMAC mimetics, are promising anticancer agents modeled after this mechanism. We investigated the role and mechanisms of Smac-...
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